cenobamate will lower the extent or effect of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Raise dose of CYP3A4 substrate, as necessary, when coadministered with cenobamate.fentanyl transdermal will boost the amount or influence of isavuconazonium sulfate by impacting hepatic/